Metformin is an FDA-approved drug used successfully to treat diabetes for more than 60 years
Studies have recently shown that metformin can delay aging in animals. There have been 20 or 30 studies that tested metformin in animal models, and the average extension of lifespan was about 7-10 percent.
Metformin has superior safety profile compared to other similar drugs and it's also low cost.
Metformin might be helping because most Americans are metabolically unhealthy. If you are a healthy person, metformin might not do much for you.
My Metformin Experience
How to get it?
I used Agelessrx to order my Metformin. They assign you a doctor to check your medical history before approving the order. I have someone in my family line who suffered from cirrhosis (See also:
Metformin can cause gastrointestinal discomfort, so AgelessRx recommends the following
Take metformin with a meal (the largest one)
Try to take it at the same time each day to help your body acclimate and reduce side effects
Slowly ramp up prescribed dose
It's ok to have upset stomach, throwing up or diarrhea when you start taking Metformin. But stomach problems persists it might be a sign of an acid health problem in the blood (lactic acidosis), so it's advised to call doctor right away.
Metformin's common reactions/benefits are less appetite, weight loss and more stable energy throughout the day.
First 2 weeks
Taking only 1 pill a day. No visible effects observed. It didn't create any gastrointestinal discomfort. It also didn't decrease my appetite.
Related studies and papers
Late life metformin treatment limits cell survival and shortens lifespan.
Metformin is widely used for treating people with type 2 diabetes and appears to show protection against cancer, inflammation, and age-related pathologies.
Many studies have confirmed the positive effect of metformin on life span of worms, flies, mice and rats.
Diabetic and cardiovascular disease patients who are prescribed metformin have increased rates of survival.
Metformin is also promising because of its superior safety profile.
Metformin and the liver
Study to assess the efficacy and safety of adding Metformin to the standard treatment for patients with HBeAg-positive chronic hepatitis B
To be completed in December 2021
Chronic infection with hepatitis B virus (HBV) often causes chronic inflammation of the liver with an increased incidence of hepatocellular carcinoma. Taking metformin may decrease inflammation which may reduce the risk of liver cancer or other major cancers in patients with HBV infection.
Metformin can prominently reduce HBsAg. Metformin can be used in drugs for reducing or eliminating serum surface antigen of hepatitis B virus.