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metformin

Metformin is an FDA-approved drug used successfully to treat diabetes for more than 60 years

Studies have recently shown that metformin can delay aging in animals. There have been 20 or 30 studies that tested metformin in animal models, and the average extension of lifespan was about 7-10 percent.

Metformin has superior safety profile compared to other similar drugs and it's also low cost.

Metformin might be helping because most Americans are metabolically unhealthy. If you are a healthy person, metformin might not do much for you.

My Metformin Experience

How to get it?

I used Agelessrx to order my Metformin. They assign you a doctor to check your medical history before approving the order. I have someone in my family line who suffered from cirrhosis (See also:

), therefore we went over my recent ALT/AST numbers. The process was quite smooth overall though.

Side Effects

Metformin can cause gastrointestinal discomfort, so AgelessRx recommends the following

Take metformin with a meal (the largest one)

Try to take it at the same time each day to help your body acclimate and reduce side effects

Slowly ramp up prescribed dose

It's ok to have upset stomach, throwing up or diarrhea when you start taking Metformin. But stomach problems persists it might be a sign of an acid health problem in the blood (lactic acidosis), so it's advised to call doctor right away.

Metformin's common reactions/benefits are less appetite, weight loss and more stable energy throughout the day.

Experience

First 2 weeks

Taking only 1 pill a day. No visible effects observed. It didn't create any gastrointestinal discomfort. It also didn't decrease my appetite.

Related studies and papers

TAME Trial, by AFAR 2020

Nationwide, six-year clinical trials at 14 leading research institutions across the country that will engage over 3000 people between 65-79.

Metformin is widely used for treating people with type 2 diabetes and appears to show protection against cancer, inflammation, and age-related pathologies.

Many studies have confirmed the positive effect of metformin on life span of worms, flies, mice and rats.

Diabetic and cardiovascular disease patients who are prescribed metformin have increased rates of survival.

Metformin is also promising because of its superior safety profile.

Metformin and the liver

Study to assess the efficacy and safety of adding Metformin to the standard treatment for patients with HBeAg-positive chronic hepatitis B

To be completed in December 2021

Chronic infection with hepatitis B virus (HBV) often causes chronic inflammation of the liver with an increased incidence of hepatocellular carcinoma. Taking metformin may decrease inflammation which may reduce the risk of liver cancer or other major cancers in patients with HBV infection.

Metformin can prominently reduce HBsAg. Metformin can be used in drugs for reducing or eliminating serum surface antigen of hepatitis B virus.

Metformin does not appear to cause or exacerbate liver injury and is often beneficial in patients with nonalcoholic fatty liver disease.

Referenced in

Lowering inflammation helps longevity

metformin has already been shown to repair broken cell machinery and drastically lower dangerous inflammation.