caloric restriction has been shown in several laboratory animal models to increase life span and slow the progression of a wide variety of age related pathologies.
CALERIE clinical trial was the first study to focus specifically on the effects of sustained calorie restriction in humans. CALERIE demonstrated favorable effects on predictors of longevity and cardio metabolic risk factors. 2 years of 12% reduction of calorie intake significantly improves cardiovascular health for young and middle-aged healthy individuals.
Related Studies and Papers
CR reduction of calorie intake to a level that doesn't compromise overall health has been considered as being one of the most promising dietary interventions to extend lifespan in humans. Because CR is not easy IF and TRF have emerged as alternatives of CR. CR and IF appear to extend lifespan.
Traditional CR robustly improves markers of aging in humans.
The primary discovery in the current study is that eating less delays the onset of age related diseases by lowering the inflammation throughout the body.
CR reduces metabolic rate and oxidative stress, improves insulin sensitivity, and alters nervous system function in animals.
Calorie restriction (CR) extends life span and retards age-related chronic diseases in a variety of species, including rats, mice, fish, flies, worms, and yeast. Why this occurs is unclear. Whether prolonged CR increases life span in humans is unknown.
It is known that drastically reducing food intake will reduce metabolic rate.
CR may result in lower levels of protein and DNA damage.